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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Microsomal ethanol oxidizing system ： ウィキペディア英語版 Microsomal ethanol oxidizing system The microsomal ethanol oxidizing system (MEOS) is an alternate pathway of ethanol metabolism that occurs in the microsome in the oxidation of ethanol to acetaldehyde. While playing only a minor role in ethanol metabolism in average individuals, MEOS activity increases after chronic alcohol consumption. The MEOS pathway requires the CYP2E1 enzyme, part of the cytochrome P450 family of enzymes, to convert ethanol to acetaldehyde. Ethanol’s affinity for CYP2E1 is lower than its affinity for alcohol dehydrogenase. It has delayed activity in non-chronic alcohol consumption states as increase in MEOS activity is correlated with an increase in production of CYP2E1, seen most conclusively in alcohol dehydrogenase negative deer mice.〔Chales S. Lieber. 2004. The Discovery of the Microsomal Ethanol Oxidizing System and Its Physiologic and Pathologic Role. ''Drug Metabolism Reviews'' 36:511-529.〕 The MEOS pathway converts ethanol to acetaldehyde by way of a redox reaction. In this reaction, ethanol is oxidized (losing two hydrogens) and O2 is reduced (by accepting hydrogen) to form H2O. NADPH is used as donor of hydrogen, forming NADP+.〔Robbins and Cotran: Pathologic basis of disease (8th edition)〕 This process consumes ATP and dissipates heat, thus leading to the hypothesis that long term drinkers see an increase in resting energy expenditure.〔Francisco Santolaria and Emilio González- Reimers. 2003. Alcohol and Nutrition: an Integrated Perspective in ''Nutrition and Alcohol: Linking Nutrient Interactions and Dietary Intake''. p. 5 Ronald Ross Watson and Victor R. Preedy (eds). Taylor and Francis, CRC Press.〕 ==References== 〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Microsomal ethanol oxidizing system」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.